Login | Users Online: 545  
Home Print this page Email this page Small font sizeDefault font sizeIncrease font size   
Home | About us | Editorial board | Search | Ahead of print | Current Issue | Archives | Submit article | Instructions | Subscribe | Advertise | Contact us
 
ORIGINAL ARTICLE
Year : 2005  |  Volume : 6  |  Issue : 1  |  Page : 31-36

The influence of statins on the free intracellular calcium concentration in human umbilical vein endothelial cells


1 Clinics for Internal Medicine I Med. Faculty of the Friedrich Schiller University, Jena, Germany
2 Unit Molecular and Cellular Biophysics Med. Faculty of the Friedrich Schiller University, Jena, Germany

Correspondence Address:
Stephan Heinke
Clinics for Internal Medicine I Med. Faculty of the Friedrich Schiller University Jena Erlanger Allee 101, D-07747 Jena
Germany
Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions

Background: Statins are cholesterol-lowering drugs that are widely used to reduce the risk of cardiac infarction. Their beneficial clinical effects, however, are not restricted to their influence on cholesterol production. As several studies have shown that they have a potency of relaxing blood vessels. Methods: We measured the effects of statins on the intracellular free calcium concentration ([Ca2+]i) in human umbilical vein endothelial cells (HUVEC) after acute application and 24-h-preincubation of statins. Results: Incubation of the cells for 24 h with cerivastatin or fluvastatin significantly increased the resting [Ca2+]i. For cerivastatin this effect manifested at a concentration of 1 ΅M. Increase of resting [Ca2+]i in the presence of cerivastatin also occurred when the nitric oxide synthase was inhibited. Transient Ca2+ release induced by histamine was not affected. Conclusions: The increase of resting [Ca2+]i after incubation with cerivastatin or fluvastatin may provide an explanation for the direct effects of statins on the endothelial-dependent vasodilatation and restoration of endothelial activity in vivo.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1755    
    Printed113    
    Emailed0    
    PDF Downloaded49    
    Comments [Add]    

Recommend this journal