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ORIGINAL ARTICLE
Year : 2008  |  Volume : 9  |  Issue : 4  |  Page : 142-151

Health-Related quality of life after myocardial infarction is associated with level of left ventricular ejection fraction


1 Norwegian Knowledge Centre for the Health Services, Oslo; Medical Division, Akershus University Hospital, Lørenskog; and Department of Pharmacotherapeutics, Faculty Division Rikshospitalet, Faculty of Medicine, University of Oslo, Oslo, Norway
2 Department of Pharmacotherapeutics, Faculty Division Rikshospitalet, Faculty of Medicine, University of Oslo, Oslo, Norway
3 Medical Division, Akershus University Hospital, Lørenskog, Norway
4 Norwegian Knowledge Centre for the Health Services, Oslo; Medical Division, Akershus University Hospital, Lørenskog; Helse Øst Health Services Research Centre, Lørenskog; and Faculty Division Akershus University Hospital, Faculty of Medicine, University of Oslo, Lørenskog, Norway

Correspondence Address:
Kjell I Pettersen
Norwegian Knowledge Centre for the Health Services, Oslo; Medical Division, Akershus University Hospital, Lørenskog; and Department of Pharmacotherapeutics, Faculty Division Rikshospitalet, Faculty of Medicine, University of Oslo, Oslo
Norway
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Source of Support: None, Conflict of Interest: None


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Background: The objective was to explore the relationship between left ventricular ejection fraction (LVEF) assessed during hospitalization for acute myocardial infarction (MI) and later health-related quality of life (HRQoL). Methods: We used multivariable linear regression to assess the relationship between LVEF and HRQoL in 256 MI patients who responded to the Kansas City Cardiomyopathy Questionnaire (KCCQ), the EQ-5D Index, and the EuroQol Visual Analogue Scale (EQ-VAS) 2.5 years after the index MI. Results: 167 patients had normal LVEF (>50%), 56 intermediate (40%-50%), and 33 reduced (<40%). The mean (SD) KCCQ clinical summary scores were 85 (18), 75 (22), and 68 (21) (p < 0.001) in the three groups, respectively. The corresponding EQ-5D Index scores were 0.83 (0.18), 0.72 (0.27), and 0.76 (0.14) (p = 0.005) and EQ-VAS scores were 72 (18), 65 (21), and 57 (20) (p = 0.001). In multivariable linear regression analysis age ≥ 70 years, known chronic obstructive pulmonary disease (COPD), subsequent MI, intermediate LVEF, and reduced LVEF were independent determinants for reduced KCCQ clinical summary score. Female sex, medication for angina pectoris at discharge, and intermediate LVEF were independent determinants for reduced EQ-5D Index score. Age ≥ 70 years, COPD, and reduced LVEF were associated with reduced EQ-VAS score. Conclusion: LVEF measured during hospitalization for MI was a determinant for HRQoL 2.5 years later.


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