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REVIEW ARTICLE
Year : 2012  |  Volume : 13  |  Issue : 2  |  Page : 53-65

Pregnancy-related spontaneous coronary artery dissection: Two case reports and a comprehensive review of literature


1 Department of Cardiology, Southend University Hospital NHS Foundation Trust, Essex, United Kingdom
2 Department of Cardiology, Addenbrooke's Hospital, Cambridge, United Kingdom

Correspondence Address:
Azeem S Sheikh
Department of Cardiology, Southend University Hospital NHS Foundation Trust, Prittlewell Chase, Westcliff-on-Sea, Essex
United Kingdom
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1995-705X.99229

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Spontaneous coronary artery dissection is a rare cause of acute coronary syndrome, particularly seen in women during pregnancy or in the puerperium. It has a high acute phase mortality. The etiology is uncertain. Hormonal changes during pregnancy, hemodynamic stress and changes in the autoimmune status have been considered as possible etiological factors. A timely diagnosis and institution of appropriate treatment is important for a successful outcome. There is no consensus of opinion for optimal treatment. Conservative management, coronary artery bypass graft surgery, and percutaneous coronary intervention, all have been described in the literature as possible therapeutic options. Spontaneous coronary artery dissection should be considered as a differential in any young woman presenting with chest pain associated with pregnancy. We report two cases of pregnancy-associated spontaneous coronary artery dissection, both successfully managed, along with a comprehensive review of the previously published literature.


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