Login | Users Online: 322  
Home Print this page Email this page Small font sizeDefault font sizeIncrease font size   
Home | About us | Editorial board | Search | Ahead of print | Current Issue | Archives | Submit article | Instructions | Subscribe | Advertise | Contact us
 
ORIGINAL ARTICLE
Year : 2014  |  Volume : 15  |  Issue : 4  |  Page : 106-110

The Role of ischemia modified albumin in acute pulmonary embolism


1 Department of Cardiology, Mevlana University, Konya, Turkey
2 Department of Cardiology, Meram School of Medicine, Necmettin Erbakan University, Konya, Turkey
3 Department of Biochemistry, Meram School of Medicine, Necmettin Erbakan University, Konya, Turkey
4 Department of Biochemistry, Mevlana University, Konya, Turkey

Correspondence Address:
Dr. Zeynettin Kaya
Department of Cardiology, Mevlana University, Yeni ?stanbul Cad. No: 235, 42003, Selçuklu, Konya
Turkey
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1995-705X.151083

Rights and Permissions

Background: Acute pulmonary embolism (PE) is a life-threatening and a relatively common cardiovascular pathology. Although the pathogenesis of PE is well defined, there is no ideal diagnostic biochemical marker. Previous studies showed an increased ischemia modified albumin (IMA) levels in acute PE; however, the relationship between IMA and right ventricular (RV) dysfunction has not been examined. The aim of this study was to evaluate the diagnostic value of IMA and the relationship with RV dysfunction in acute PE. Materials and Methods : A total of 145 patients (70 females) with suspected acute PE was enrolled to the study. Eighty-nine patients were diagnosed with acute PE via computed tomographic pulmonary angiography. Sixty-five patients with similar demographic and clinical characteristics were assigned to the control group. All patients were evaluated for RV dysfunction using transthoracic echocardiography. Results: Serum IMA levels were significantly increased in acute PE compared with control group (0.41 ± 0.06 vs. 0.34 ± 0.11, P = 0.001). There was no relationship between serum IMA levels and RV dysfunction. IMA levels were positively correlated with shock index and heart rate. Receiver operating curve analysis demonstrated that serum IMA levels higher than 0.4 put the diagnosis at sensitivity of 53.85% and at specificity of 85.96%. Conclusions: Although IMA levels are increased in patients with acute PE, it failed to predict RV dysfunction.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1316    
    Printed38    
    Emailed1    
    PDF Downloaded128    
    Comments [Add]    
    Cited by others 1    

Recommend this journal