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Year : 2001  |  Volume : 2  |  Issue : 1  |  Page : 16-19

Aggressive lipid lowering in patients with coronary heart disease

2nd Department of Medicine, Krankenanstalt Rudolfstiftung, Vienna, Austria

Correspondence Address:
Ronald Karnik
2nd Department of Medicine, Krankenanstalt Rudolfstiftung, Juchgasse 25, A-1030 Vienna
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Source of Support: None, Conflict of Interest: None

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Atherosclerosis is by far the most frequent cause of coronary heart disease (CHD). Large studies have provided unequivocal evidence that lipid lowering by statins significantly reduce the incidence of CHD endpoints. New insights in the pathophysiology show that statin therapy reduces progression of atherosclerosis, and leads to plaque stabilization as well as a reduced plaque thrombogenicity. In patients with CHD, treatment with statins may prevent plaque rupture of atherosclerotic lesions and therefore reduces the occurrence of acute coronary syndromes. Patients with hemodynamically relevant stenosis and angina interfering with quality of life and patients who have less exercise tolerance may be regarded as candidates for coronary intervention. In these patients, aggressive lipid-lowering may complement angioplasty by stabilizing untreated lesions. According to the guidelines of the National Cholesterol Educational Program, LDL-cholesterol of no more than 100mg/dl is considered optimal in patients with CHD or other atherosclerotic diseases.

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