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ORIGINAL ARTICLE
Year : 2001  |  Volume : 2  |  Issue : 1  |  Page : 20-24

Early results of combined therapy with lisinopril and irbesartan in patients with dilated cardiomyopathy and chronic renal failure


1 Department of Cardiology and Coronary Intensive Care Unit, Fatebenefratelli Hospital, Rome, Italy
2 Department of Geriatrics, Gerontology and Metabolic Diseases, Second University of Naples – Naples –, Italy

Correspondence Address:
Gianluca Di Micco
C.so Europa 9, 80131 Napoli
Italy
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Source of Support: None, Conflict of Interest: None


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This paper reports a clinical observational and multi-parametric study performed in a series of elderly patients with dilated cardiomyopathy and kidney failure. Elderly patients affected by dilated cardiomyopathy and kidney failure are usually treated with digitalis, diuretic and angiotensin converting enzyme inhibitors (ACE-I). Thirty elderly patients with dilated cardiomiopathy and kidney failure were enrolled and treated with digitalis, diuretic, full dosage angiotensin II receptor antagonists (irbesartan 150 mg daily) and low dosage ACE-I (lisinopril 5 mg daily). Patients were followed by physical examination, laboratory tests (serum creatinine, creatinine clearance 24hrs urine sample) to monitor kidney function. To evaluate the evolution of dilated cardiomyopathy, patients were follow-up with electrocardiogram and echocardiography. Data were expressed as mean and statistical analysis was performed with Student’s t-test for paired data. At 90-day follow-up we found relevant clinical and laboratory reduction of mean creatinine levels (1.73 mg/dl versus 2.13 mg/dl; p= 0.65). There was an increase in mean creatinine clearance (24hrs urine sample) 79.43 ml/min versus 59.11 ml/min; p= < 0.05). Electrocardiographic and echocardiographic parameters also improved. Such good results could be related to more effective antagonism of angiotensin II, which is not only produced by ACE but also through other pathways.


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