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Year : 2012  |  Volume : 13  |  Issue : 3  |  Page : 91-96

A study of atherosclerosis in patients with chronic renal failure with special reference to Carotid Artery Intima Media Thickness

1 Department of Medicine, Burdwan Medical College, West Bengal, India
2 Department of Radiology, Burdwan Medical College, West Bengal, India
3 Department of General Medicine, N R S Medical College, West Bengal, India

Correspondence Address:
Jayanta Paul
Department of General Medicine, Burdwan Medical College,C/o Jitendra Chandra Paul, J+B lodge, Santosh Sarani,Banamali Pur, Barasat, North 24 Parganas, West Bengal - 700124
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1995-705X.102147

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Objectives: Cardiovascular disease is the leading cause of morbidity and mortality in patients with chronic renal failure (CRF). This study attempts to identify the factors responsible for atherosclerosis in CRF patients using carotid artery intima media thickness (CAIMT) as a surrogate marker of atherosclerosis. Materials and Methods: CAIMT was measured by high-resolution B-mode ultrasonography in 100 CRF patients and 50 age- and sex-matched healthy controls. Data were analyzed by software SPSS (17 th version) for Windows. Results: CRF patients had a significantly higher CAIMT (1026.83 ± 17.19 micron, mean ± SE, P < 0.001) than age- and sex-matched healthy controls (722.46 ± 7.61 micron). There was inverse correlation between CAIMT and glomerular filtration rate (GFR) (P < 0.001) independent of traditional risk factors. There was also significant positive correlation between CAIMT and traditional risk factors of atherosclerosis. Ischemic heart disease (IHD) also showed positive correlation with CAIMT (P = 0.007) and inverse correlation with GFR (P = 0.005). Conclusions: There is high prevalence of atherosclerosis in CRF patients. CAIMT can be used to detect and predict future incidence of IHD in CRF patients.

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