Angiographic findings after supplementation with Heracleum persicum extract: Results of a randomized controlled trial

Yunes Panahi; Bahram Pishgoo; Amirhossein Sahebkar

doi:10.4103/1995-705X.164462

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ORIGINAL ARTICLE

Year : 2015 | Volume : 16 | Issue : 3 | Page : 85-87

Angiographic findings after supplementation with Heracleum persicum extract: Results of a randomized controlled trial

Yunes Panahi¹, Bahram Pishgoo², Amirhossein Sahebkar³
¹ Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
² Department of Cardiology, Cardiovascular Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
³ Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Metabolic Research Centre, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Australia

Correspondence Address:
Dr. Amirhossein Sahebkar
Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, P.O. Box: 91779-48564, Iran

Source of Support: This study was financially supported by the Clinical Trial Research Center, Tehran, Iran., Conflict of Interest: None declared.

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DOI: 10.4103/1995-705X.164462

Background: Heracleum persicum is a common dietary spice with several traditional medicinal properties important for cardiovascular health including antioxidant, hypolipidemic, and anti-inflammatory effects. This study explored the effects of supplementation with H. persicum fruit on the angiographic findings of patients with minimal coronary artery disease (CAD). Methods: Subjects who were diagnosed with <50% stenosis in any of their coronary arteries by angiography were selected for this trial and randomly assigned to H. persicum hydroalcoholic fruit extract (n = 15; 300 mg/day) or placebo (n = 12) for 6 months. At the end of the trial, participants underwent a second coronary angiography in order to evaluate the progression of their disease. Results: Posttrial angiography did not reveal any improvement in the number of stenosed vessels after consumption of H. persicum extract versus placebo (P > 0.05). Similarly, there was no significant difference between the study groups in terms of disease progression and chest pain score (P > 0.05). Conclusions: The present results do not support any clinically significant benefit of supplementation with H. persicum extract on the angiographic findings of in patients with minimal CAD.

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