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Table of Contents
CASE REPORT
Year : 2017  |  Volume : 18  |  Issue : 1  |  Page : 26-29  

External compression of epicardial coronary arteries with partial calcific pericarditis


1 Department of Cardiovascular Diseases, Cooper University Hospital, Camden, NJ, USA
2 Department of Cardiovascular Diseases, Cooper University Hospital, Camden, NJ; Department of Cardiovascular Diseases, Alpert School of Medicine, Brown University, RI, USA

Date of Web Publication15-May-2017

Correspondence Address:
Muhammad Rizwan Sardar
Alpert School of Medicine, Brown University, RI 02903
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1995-705X.206207

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   Abstract 

Calcific pericarditis(CP) is a rare disease which results from long-standing pericardial inflammation. Pericardial calcification may completely or partially encase the ventricles, resulting in impaired diastolic filling. We present a case of a 53-year-old male who was incidentally found to have annular CP resulting in external compression of a large territory diagonal branch(D1) reaching the apex with likely chronically occluded left anterior descending artery with collateral circulation from the right coronary artery with hemodynamic compromise on coronary angiography. This was emergently treated with a drug-eluting stent with improved D1 flow and entailed the importance of percutaneous coronary intervention as a viable option in cases of CP resulting in acute hemodynamic compromise.

Keywords: Acute coronary syndrome, calcific pericarditis, percutaneous coronary intervention


How to cite this article:
Khan ZA, Sardar MR, Topalian SK. External compression of epicardial coronary arteries with partial calcific pericarditis. Heart Views 2017;18:26-9

How to cite this URL:
Khan ZA, Sardar MR, Topalian SK. External compression of epicardial coronary arteries with partial calcific pericarditis. Heart Views [serial online] 2017 [cited 2021 Sep 24];18:26-9. Available from: https://www.heartviews.org/text.asp?2017/18/1/26/206207


   Introduction Top


Calcific pericarditis(CP) presents as a long-term sequela of pericardial inflammation or local injury. This causes a normal pliable fibroelastic pericardium to thicken with rigid secondary to scarring and, dense fibrosis which impedes ventricular diastolic filling.[1] While constrictive physiology usually results from encasement of both ventricles, partial CP, presenting as bands of calcium, may only result in localized compressive symptoms or partial constriction.[2]


   Case Report Top


A 53-year-old male presented to an outpatient office for an epidural injection for chronic back pain. Presenting vital signs showed a blood pressure of 106/62mmHg and tachycardia with a pulse rate of 135 bpm. He reported a week history of dyspnea on moderate to severe exertion but denied any history of palpitations, syncope, near syncope, or chest pain.

Past medical history revealed significant hypertension and diabetes mellitus which controlled with diet. He was a former roofer and denied smoking, alcohol or illicit drug use.

Electrocardiogram in office showed new onset atrial flutter with variable atrioventricular block. He was sent to emergency room(ER) where he was started on diltiazem and heparin infusions. Soon after his arrival in ER, he became diaphoretic, hypoxic, complained of substernal chest pain, and sustained a cardiac arrest with pulseless electrical activity. Subsequent electrocardiogram after successful resuscitation showed atrial flutter with evidence of anterior ischemia.

Blood cell counts and thyroid-stimulating hormone levels were within normal limits while basic metabolic panel was significant for creatinine of 1.4mg/dl which subsequently rose to 3.4mg/dl on postresuscitation. Troponin-I levels which were initially negative rose up to 1.17ng/dl. Chest radiograph showed cardiomediastinal silhouette enlargement with mild congestion and pleural opacity on the right chest wall [Figure1]. Echocardiogram revealed moderately depressed left ventricular ejection fraction with anterior wall hypokinesis and pericardial thickening [Figure2].
Figure 1: Presenting chest radiograph showing cardiomediastinal silhouette enlargement with mild congestion and pleural opacity on the right chest wall. Annular calcific pericardial ring later seen on echocardiogram, coronary angiography, and computed tomography scan is not well visualized

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Figure 2: Presenting echocardiogram showing pericardial calcification. (a) Apical four chamber and parasternal short axis. (b) Views showing pericardial thickening (shown by arrows)

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With ongoing hemodynamic instability, evidence of ischemia and elevation in cardiac enzymes, he was taken for emergency catheterization.

Coronary angiography revealed subtotal occlusion of mid-left anterior descending(LAD), first diagonal, and obtuse marginal arteries secondary to external compression by a calcific band, which was also confirmed on intravascular ultrasound[Figure3]a,[Figure3]b,[Figure3]c and [Supplemental Video 1]. The right coronary artery had mild luminal irregularities giving of collaterals to distal LAD[Figure3]d and [Supplemental Video 2]. Intra-aortic balloon pump(IABP) was placed for hemodynamic support with successful placement of a drug-eluting stent to improve flow in the first diagonal branch which was thought to be the culprit vessel considering the presence of collaterals to distal LAD from the right coronary artery[Figure3]e,[Figure3]f and [Supplemental Video 3].
Figure 3: Coronary angiography and intravascular ultrasound imaging at baseline and postangioplasty. (a) Initial angiography showing subtotal occlusion of mid-left anterior descending artery, distal first diagonal (D1), and obtuse marginal branches secondary to external compression by calcific band (shown by arrows) [Supplemental Video 1]. (b) Calcific band seen on fluoroscopy across anterior atrioventricular groove. (c) Intravascular ultrasound showing the intravascular ultrasound catheter hugging the D1 lumen with external compression by calcific ring seen as layers of extravascular calcium and resulting shadowing artifact (*). (d) Collaterals seen from the right coronary artery to distal left anterior descending with late filling of distal left anterior descending (shown by arrows) [Supplemental Video 2]. (e) Successful deployment of a 2.5 mm × 28 mm drug-eluting stent in D1 branch. (f) Postpercutaneous coronary intervention results with improvement in D1 flow [Supplemental Video 3]

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Aproper evaluation for constrictive physiology was deferred due to patient's hemodynamic instability requiring IABP. Findings of localized CP were later confirmed by computed tomography sca [Figure4]a and [Figure4]b with hemodynamic improvement.
Figure 4: Reconstructed computed tomography scan image showing the calcific ring (a) and the distal first diagonal artery stent (arrow) crossing underneath the calcific band (b)

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An extensive infectious workup for etiology of CP was performed along with serum antinuclear antibody and rheumatoid factor which were all negative. He was eventually planned to return to catheterization laboratory for evaluation of constrictive physiology. However, he developed hypercarbic respiratory failure with pulseless electrical activity. Recurrent percutaneous coronary intervention (PCI) and was unable to be revived.

Autopsy was performed which revealed cause of death to be massive right pulmonary hemorrhagic infarct[Figure5]a. Extensive adhesions were found between pleura and chest wall. Severe calcific, complex atherosclerosis of proximal to mid-left anterior and proximal to mid-left circumflex arteries was seen with a patent and intact recently placed mid-LAD artery stent[Figure5]b. Fibrocalcific constrictive pericarditis with a constrictive annular band in atrioventricular groove was noted with dense fibrosis and calcification[Figure5]c, but no ongoing inflammation and no explanation for the healed pericarditis on microscopy. Despite the occupational history, no mesothelioma or asbestos-related lung disease was identified.
Figure 5: Autopsy gross specimens of lungs and heart. (a) Lung gross specimen showing pulmonary thromboemboli with massive right pulmonary hemorrhagic infarct and pleural hemorrhage which was thought to be the cause of death. (b) Dissected specimen of left anterior groove with patent and intact recently placed first diagonal artery stent (arrow). (c) Gross specimen of heart with hypertrophied left ventricle and fibrocalcific constrictive annular band in atrioventricular groove (arrow) with dense fibrosis and calcification

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   Discussion Top


CP is a rare disease, which results from long-standing pericardial inflammation. Common etiologies include tuberculosis in developing countries while postsurgical constriction, radiation, neoplasms, and systemic diseases are more common culprits in the western world. However, majority of the cases remain idiopathic; and as in our case, histologic examination of calcified pericardium rarely provides specific diagnoses.

Pericardial calcification varies in its presentation encasing some but not all chambers of the heart with variable degrees of compression. In some instances, nonuniform indentations, such as in our case, may result in external compression of epicardial coronary arteries which have been reportedly treated with pericardiectomy.[3],[4] Two cases of annular CP successfully treated with angioplasty with good outcomes have been reported.[5],[6] In both instances, patients had a history of rheumatoid arthritis with pleuritic and thoracic surgeries.

In our case, the etiology of annular CP remained unclear; it was postulated that chest compressions during cardiopulmonary resuscitation may have played a role in the compression of epicardial coronary vessels in the presence of the external calcific band.

Clinically significant cases of CP require eventual pericardiectomy; however, PCI can be utilized in cases with fixed external compression of epicardial coronary circulation with acute hemodynamic compromise.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

 
   References Top

1.
RobertsWC. Pericardial heart disease: Its morphologic features and its causes. Proc(Bayl Univ Med Cent) 2005;18:38-55.  Back to cited text no. 1
[PUBMED]    
2.
HutchisonSJ. Pericardial constriction variants. Pericardial Diseases: Clinical Diagnostic Imaging Atlas. 1sted. Philadelphia: Saunders Elsevier; 2008. p.187-222.  Back to cited text no. 2
    
3.
BhagiaST, PatelAR, ReulGJ. Coronary obstruction by a calcific pericardial ring. Ann Thorac Surg 2002;74:595-7.  Back to cited text no. 3
[PUBMED]    
4.
MatsunoY, ShimabukuroK, IshidaN, TakemuraH. Off-pump complete pericardiectomy for an unusual case of annular constrictive pericarditis. Ann Thorac Surg 2012;94:e45-7.  Back to cited text no. 4
[PUBMED]    
5.
GaurS, JensenJM, TerkelsenCJ, HolmNR, Nørgaard BL. Entrapment of the left anterior descending coronary artery by localized calcific pericarditis: From dynamic to fixed coronary stenosis. Circulation 2013;128:e30-1.  Back to cited text no. 5
    
6.
HsiDH, McGrathLB, SalamatJ, SimonM, GeorgeJC. Epicardial coronary artery compression secondary to pericardial adhesions demonstrated by multi-modality imaging, and treated by coronary stenting. Circulation 2014;130:e129-30.  Back to cited text no. 6
[PUBMED]    


    Figures

  [Figure1], [Figure2], [Figure3], [Figure4], [Figure5]


This article has been cited by
1 Occlusion of Epicardial Coronary Arteries by Localized Pericardial Calcification
Yassin N. Yassin,Pavol Tomasov,Jan Horak,Rostislav Polasek
JACC: Case Reports. 2019; 1(4): 671
[Pubmed] | [DOI]



 

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