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CASE REPORT
Year : 2020  |  Volume : 21  |  Issue : 4  |  Page : 296-299

Severe right-sided heart failure and pulmonary hypertension with carfilzomib treatment in multiple myeloma


1 Division of Cardiovascular Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA
2 Division of Hematology and Oncology, University of Arkansas for Medical Sciences, Little Rock, AR, USA

Correspondence Address:
Dr. Angel Lopez-Candales
Department of Internal Medicine, Division of Cardiology, University of Arkansas for Medical Sciences, 4301 W. Markham Street, #532, Little Rock 72205, AR
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/HEARTVIEWS.HEARTVIEWS_107_20

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Carfilzomib, a second-generation irreversible proteasome inhibitor, is currently considered the preferred therapy for relapsed and refractory multiple myeloma. There are several cardiovascular adverse effects described with carfilzomib chemotherapy most commonly being hypertension, dyspnea and decreased cardiac ejection fraction. We report a case of newonset pulmonary hypertension with right ventricular (RV) heart failure in a patient receiving carfilzomib. Awareness of this rare side effect of this drug is essential for prompt diagnosis and management. We also propose close monitoring of RV and pulmonary artery pressures along with left ventricular function in echocardiographic assessment in patients with carfilzomib chemotherapy.


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