Login | Users Online: 4300  
Home Print this page Email this page Small font sizeDefault font sizeIncrease font size   
Home | About us | Editorial board | Search | Ahead of print | Current Issue | Archives | Submit article | Instructions | Subscribe | Advertise | Contact us
Year : 2020  |  Volume : 21  |  Issue : 4  |  Page : 296-299

Severe right-sided heart failure and pulmonary hypertension with carfilzomib treatment in multiple myeloma

1 Division of Cardiovascular Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA
2 Division of Hematology and Oncology, University of Arkansas for Medical Sciences, Little Rock, AR, USA

Correspondence Address:
Dr. Angel Lopez-Candales
Department of Internal Medicine, Division of Cardiology, University of Arkansas for Medical Sciences, 4301 W. Markham Street, #532, Little Rock 72205, AR
Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and Permissions

Carfilzomib, a second-generation irreversible proteasome inhibitor, is currently considered the preferred therapy for relapsed and refractory multiple myeloma. There are several cardiovascular adverse effects described with carfilzomib chemotherapy most commonly being hypertension, dyspnea and decreased cardiac ejection fraction. We report a case of newonset pulmonary hypertension with right ventricular (RV) heart failure in a patient receiving carfilzomib. Awareness of this rare side effect of this drug is essential for prompt diagnosis and management. We also propose close monitoring of RV and pulmonary artery pressures along with left ventricular function in echocardiographic assessment in patients with carfilzomib chemotherapy.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded24    
    Comments [Add]    

Recommend this journal