|Year : 2022 | Volume
| Issue : 2 | Page : 78-85
Long-term outcomes of tetralogy of fallot in the Kingdom of Bahrain
Abhinav Agarwal1, Suad R Al Amer2, Habib Al Tarif1, Aieshah Ahmed Ismael1, Abdulla Faisal Alshaiji1, Vimalarani Arulselvam1, Neale Nicola Kalis2
1 Mohammed Bin Khalifa Bin Salman Al-Khalifa Cardiac Center, Bahrain Defense Forces Hospital, Awali, Kingdom of Bahrain
2 Mohammed Bin Khalifa Bin Salman Al-Khalifa Cardiac Center, Bahrain Defense Forces Hospital, Awali; Department Pediatric Cardiology, Royal College of Surgeons of Ireland – Medical University of Bahrain, Muharraq, Kingdom of Bahrain
|Date of Submission||23-Jul-2021|
|Date of Acceptance||14-Jun-2022|
|Date of Web Publication||23-Jul-2022|
Prof. Neale Nicola Kalis
The Mohammed Bin Khalifa Bin Salman Al-Khalifa Cardiac Center, Bahrain Defense Force Hospital, PO Box 28743, Awali
Kingdom of Bahrain
Source of Support: None, Conflict of Interest: None
| Abstract|| |
Introduction: Tetralogy of Fallot (TOF) is the most common cyanotic congenital heart disease. Surgical correction has improved survival but re-intervention is often required.
Objectives: The objective is to assess outcomes after surgical repair of TOF, long-term follow-up, and factors that influence these results.
Materials and Methods: This is a retrospective study conducted in a tertiary care center. Records of patients diagnosed with TOF from 1992 to 2019 (37 years) were retrieved from a detailed database. Patients who underwent complete correction were grouped according to diagnosis, the technique utilized in surgical repair, need for staged repair, and syndromic association. Univariate actuarial and event-free survival analysis was performed. The endpoint for an event was death or re-intervention.
Results: A total of 230 patients were diagnosed with TOF and 174 patients underwent complete surgical repair. At 40 years postoperatively, survival was 96%. Actuarial survival was independent of syndromic associations, anatomical diagnosis, type of surgery, or previous shunt. Event-free survival (EFS) survival was 8.12%. EFS was significantly worse for patients with pulmonary atresia (PA) (Hazard ratio, 4.1125; 95% confidence interval [CI], 1.2654–13.3657; P < 0.0001) and for those that required homograft/conduit. The median duration for EFS was 22.73 years, 19.58 years, and 9.12 years for transannular patch (TAP), pulmonary valve-sparing (PVS), and homograft group, respectively. The survival curve for the PVS group merged with that of TAP 20 years postoperatively. Similarly, it merged at 22 years for staged versus primary repair and at 22.73 years for syndromic versus nonsyndromic patients. A weak correlation was found between age at surgery and event-free duration (cc, 0.309; P < 0.0001). The need for TAP was not influenced by the previous palliation, χ2 (1, n = 154) = 3.36, P = 0.0667, or with interval to complete correction after the shunt procedure (P = 0.9672).
Conclusions: Total correction of TOF has low perioperative mortality and good long-term survival, but the need for re-interventions is high. This study demonstrated that patients requiring homograft/conduit and those with a diagnosis of PA had worse outcomes. Comparison between different surgical groups showed merging of survival curves in follow-up that signifies gradual loss of survival advantage over time.
Keywords: Follow-up, survival analysis, Tetralogy of Fallot
|How to cite this article:|
Agarwal A, Al Amer SR, Al Tarif H, Ismael AA, Alshaiji AF, Arulselvam V, Kalis NN. Long-term outcomes of tetralogy of fallot in the Kingdom of Bahrain. Heart Views 2022;23:78-85
|How to cite this URL:|
Agarwal A, Al Amer SR, Al Tarif H, Ismael AA, Alshaiji AF, Arulselvam V, Kalis NN. Long-term outcomes of tetralogy of fallot in the Kingdom of Bahrain. Heart Views [serial online] 2022 [cited 2023 Nov 29];23:78-85. Available from: https://www.heartviews.org/text.asp?2022/23/2/78/351874
| Introduction|| |
Tetralogy of Fallot (TOF) is the most common cyanotic congenital heart disease with an incidence of 4 per 10,000 live births. Before corrective surgery, survival was only 50% beyond the first few years of life and very few patients reached adulthood. The first corrective surgery of TOF was attempted by Lillehei in 1954. From the earliest era of total correction, results were good with most of the patients reaching adulthood, however, long-term survival is still lower than that of the general population. After complete correction, there is often a need for interventions for residual lesions.,, This largely depends on whether the pulmonary valve was spared (PVS) during a complete correction or whether a transannular patch (TAP) or homograft/conduit is implanted.,
The incidence of TOF in Bahrain is higher than in international data (5.9/10,000 live births). Here, the surgical treatment of TOF started with the insertion of the Blalock–Thomas–Taussig shunt (BTS) in 1986. The first total correction of TOF was done in 1995. Before that, patients were referred abroad. This study aimed to review our results of surgical repair of TOF and their long-term follow-up.
| Materials and Methods|| |
In this retrospective study, the records of all patients diagnosed with TOF from 1992 to 2019 (37 years) were retrieved from a detailed database. Patients operated outside Bahrain but being followed up here were also included in the follow-up analysis. Patients with additional complex cardiac lesions were excluded from the study, for example, those with TOF and atrioventricular septal defects. Patients who underwent complete correction were compared based on diagnosis, i.e., TOF without pulmonary atresia (PA) versus TOF with PA, the type of surgery required, i.e., PVS, TAP, or homograft/conduit placement, and between patients with and without syndromic association. Survival analyses also compared patients who underwent palliative shunt procedures (categorized as staged repair) before complete correction to those with primary correction.
Shapiro–Wilk test was applied to analyze the normality of quantitative data. Normal data are described as mean with standard deviations and analyzed with Student's t-test or one-way ANOVA. Non-normal data are represented as median and range and analyzed with the Kruskal–Wallis test or a Mann–Whitney U test as and when appropriate. Spearman rank correlation was utilized to assess the correlation between nonnormal quantitative data. Categorical variables were summarized as frequencies and percentages and analyzed with Chi-square or Fisher's exact test as and when appropriate. The probability of long-term survival was estimated using the Kaplan–Meier survival analysis method (KM analysis) and represented in graphs. Differences between groups were calculated by the log-rank test. Log-rank analysis was not utilized when survival curves crossed and the proportional hazards assumption did not hold. For analyzing long-term actuarial and event-free survival (EFS), steep, nonlinear, the first phase of survival curves was excluded which is due to mortalities experienced in the immediate perioperative period. The event was defined as death or re-intervention due to any cause. Statistical analyses were facilitated with the help of Data was analyzed by using SPSS Statistics for Windows, Version 23.0 (IBM SPSS Statistics for Windows, Version 23.0. Armonk, NY: IBM Corp).
| Results|| |
A total of 230 patients were diagnosed with TOF. 174 patients underwent complete surgical repair. Their demographic and surgical details are summarized in [Table 1] and [Table 2]. 39 patients had incomplete long-term follow-up data and were excluded from the long-term analysis. 14 patients are awaiting surgery and 3 patients died before surgical correction.
|Table 2: Surgical details of tetralogy of fallot patients categorized according to type of surgery|
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Age at surgery
A gradual decline in surgical age was observed over the study period, except for a few patients who were referred late [Figure 1].
Details of patients who underwent complete surgical correction are described in [Table 2]. 24 patients who were operated on before 1995 were referred outside Bahrain for surgical correction and are also included in the follow-up analysis. Total perioperative mortality was 4.6%.
The median duration of follow-up was 5.42 years (range from 0 to 43.9). Actuarial 5-, 10-, 20-, 30-, and 40-year survival rates in 166 patients who survived the perioperative period were 97.4%, 96%, 96%, 96%, and 96%, respectively [Figure 2]. During follow-up, 3 mortalities were experienced in the TAP group (1 due to sepsis, 1 during re-intervention, and 1 sudden cardiac death) and 1 sudden cardiac death in the homograft group.
|Figure 2: Kaplan–Meier graph actuarial and event-free survival (years) probability (event = re-intervention or death) in patients who survived the perioperative period after complete correction. (Vertical lines represent censored patients, number of patients at risk are displayed in table below the graph)|
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Survival according to diagnosis
Among PS patients, the need for TAP was influenced neither by previous palliation, χ2 (1, n = 154) = 3.36, P = 0.0667 nor with interval to complete correction after the shunt procedure (P = 0.9672). Of 166 TOF patients who survived the perioperative period following complete correction 17 were PA and 3 were absent pulmonary valve (APV). All the patients had excellent long-term actuarial survival irrespective of diagnosis. Patients with APV were insufficient for detailed long-term survival statistical analysis.
Survival according to the type of surgical procedure
Patients were grouped according to the type of surgery (TAP, PVS, or homograft) for long-term survival comparison. All three groups had excellent actuarial survival with insignificant variation [Figure 3].
|Figure 3: Survival following different types of TOF repair. Perioperative mortality (years) after TOF repair is excluded. (Vertical lines represent censored patients, number of patients at risk are displayed in table below the graph). TOF: Tetralogy of Fallot|
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Survival according to previous palliative operations
Around one-third of the patients (n = 52 [29.9%]) underwent primary palliation (peripheral shunt or central shunt) before complete correction [Table 2]. 37 (24%) patients with PS and 15 (88.2%) patients with PA underwent staged repair. The median age at the time of palliation was around 2 months (range, 0.02–3.46 years) and the median interval to definitive correction was 1.52 years (range, 0.52–11.86 years). Five patients required a second shunt surgery. Actuarial survival was indifferent in comparison between primary repair and staged repair groups.
Survival according to the syndromic association
Fifty-six patients (24.3%) had syndromic associations described in [Table 1]. Among them, 46 (82.1%) underwent complete correction, of which 8 (17.4%) had homograft, 13 (28.3%) had valve-sparing surgery, and remaining 25 (54.3%) underwent TAP. Both syndromic and nonsyndromic patients had similar long-term actuarial survival of > 96%.
Details of all the events are described in [Table 3]. EFS at 5-, 10-, 20-, 30-, and 40-years was 86.2%, 77.7%, 56.3%, 24.4%, and 8.12%, respectively. Median EFS was 21.85 years (95% confidence interval [CI], 18.930–43.960 years) [Figure 2]. A significant but weak correlation was found between age at surgery and event-free duration (cc, 0.309; P < 0.0001).
|Table 3: Detail of events (re.intervention or death) after complete correction for patients who survived perioperative period|
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Event-free survival according to diagnosis
EFS for PA patients after the complete correction was worse than for patients with classical TOF [Figure 4] (Hazard ratio, 4.1125; 95% CI, 1.2654–13.3657; P < 0.0001). Median survival was only 8.9 years for PA patients compared to 22.73 years for pulmonary stenosis (PS) patients.
|Figure 4: Event-free survival (years) for patients according to diagnosis. Perioperative mortality after TOF repair is excluded. (Vertical lines represent censored patients, number of patients at risk are displayed in table below the graph). TOF: Tetralogy of Fallot|
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Event-free survival according to the type of surgical procedure
The median duration for EFS was 22.73 years, 19.58 years, and 9.12 years for TAP, PVS, and homograft groups, respectively. Although there was an early survival benefit of preserving the pulmonary valve during surgery over other methods [Figure 5]. At a postoperative duration of 19.58 years, this survival benefit is lost and survival curves crossed. All the patients needed some re-intervention by, 32 years in the PVS group and by 43 years in the TAP group. 16 (17.8%) patients in TAP group, 2 (3.6%) in PVS and 4 (19.0%) in homograft group required multiple re-interventions.
|Figure 5: Event-free survival following different types of TOF repair (years). (Perioperative mortality after TOF repair is excluded. Vertical lines represent censored patients, number of patients at risk are displayed in table below the graph). TOF: Tetralogy of Fallot|
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Event-free survival according to previous palliative operations
Median EFS for patients with staged repair (15.12 years) was lower than primary repair (21.85 years) and crossing of the curve was observed at 21.85 years [Figure 6].
|Figure 6: Event-free survival (years) for patients with or without primary palliation. Perioperative mortality after TOF repair is excluded. (Vertical lines represent censored patients, number of patients at risk are displayed in table below the graph). TOF: Tetralogy of Fallot|
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Event-free survival according to the syndromic association
Median survival was 22.730 years for patients without syndromic associations, whereas it was only 9.12 years for patients with syndromes with an intersection at 22.73 years [Figure 7].
|Figure 7: Event-free survival (years) for patients with or without syndromic association. Perioperative mortality after TOF repair is excluded (Vertical lines represent censored patients, number of patients at risk are displayed in table below the graph). TOF: Tetralogy of Fallot|
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| Discussion|| |
TOF is the most common cyanotic congenital heart disease and its successful surgical correction started as early as the 1950s. Studies describing the long-term follow-up in Middle Eastern countries are scarce. This study presents our long-term experience after the correction of TOF in Bahrain.
We had perioperative mortality of 4.6% which is equivalent to others that ranges from 3% to 7.8%.,,,,,,, The gradual reduction in the mean age of surgery over the study period was seen and is similarly described by others., It is the direct result of increasing experience and confidence of the surgical team over time, in the management of pre- and post-operative cases.
Patients who survive the perioperative period have excellent long-term actuarial survival.,, In this study, a 96% actuarial survival probability at 40 years reflects similar findings. This is irrespective of syndromic associations, diagnosis, type of surgery, or previous shunt. Actuarial survival with EFS showed a gradual decline with time and a 96% actuarial survival at 40 years postoperatively correlates with only 8.12% of EFS [Figure 2]. This indicated that although almost all of the patients are alive at long-term follow-up, few have an uneventful course. These results are comparable to previous studies describing a high rate of re-interventions in follow-up after TOF correction.,,,, There was also a weak correlation between the age of surgery and event-free duration.
Studies have contradicting results over survival analysis between different surgical options. Some conclude that there are no significant differences.,,,,,,,,, Our study corroborates with Murphy et al., and others as long-term actuarial survival was similar in all surgical groups irrespective of technique utilized in repair.
Similar results cannot be described for EFS as most of the patients in our study, irrespective of the type of surgery needed a second procedure after long-term follow-up. Our data shows a non-sustained early EFS benefit of PVS during surgery over TAP which eventually equalized at around 20 years in follow-up [Figure 5]. All the patients in the PVS or TAP groups required re-intervention in long term. Other studies have also described no difference in long-term follow-up among these groups.,,, PVS is not as advantageous as previously thought and the loss of survival advantage of PVS over TAP can be attributed to the progressive nature of pulmonary regurgitation (PR)., It has also been reported earlier that as much as 20% of patients in the PVS group can develop moderate PR within 1st year after surgery.,,
Homograft/conduit placement has a worse prognosis compared to PVS and TAP [Table 2]. This finding shows that the homograft and TAP group require re-interventions earlier than the PVS group [Figure 4] and also that the re-intervention rate and need for multiple re-interventions are higher in these groups [Table 2] and [Table 3]. Similar findings have also been reported by others who have demonstrated a significantly higher risk of reoperation in the TAP group, as early as 5 years after complete correction.,,,,,,
A mild right ventricular outflow tract (RVOT) gradient is shown to be advantageous in reducing the need for future pulmonary valve replacements (PVR), thus inclination towards preservation of pulmonary valve and intentionally leaving a small gradient in RVOT, has led to a higher incidence of residual RVOT obstruction and lower EFS in PVS group.,, However, this policy is still not utilized at our center.
This study is unique in that it shows the crossing of survival curves in long-term, which signifies that the effect of the type of surgery is not constant and the survival benefit is lost over time. This can explain the contradicting results of earlier studies. We also found a significant difference in follow-up duration among these three categories which is mainly driven by the TAP group [Table 2]. The fact responsible for this observation is that in the early surgical era surgeons had a preference for TAP and utilization of PVS or homograft strategy was implemented later.
Evidence favoring primary palliation versus primary repair is contradictory with studies supporting either strategy.,,,,,, Even though earlier studies have shown that BTS may help in annular growth and reduce the requirement of TAP during complete repair,,, this finding was not true in our study. In this study, a significant difference was observed in the need for staged surgery between different surgical groups (P < 0.001) which was mainly driven by the PA-homograft group [Table 2]. Also as there is a preference for delayed repair if homograft is utilized, it resulted in a significant increase in the interval to total correction [Table 2]. Earlier studies have described a higher requirement of PVR in patients with staged repair during follow-up.,,, Our follow-up analysis did show some short-term benefits after complete correction but it got negated with age and EFS probability became similar by 22 years' postoperative. This initial difference can be the result of a biased selection of cases for staged repair among whom the effect of poor anatomy decreases as the child grows and thus in the long-term outcome is equivalent with either strategy [Figure 5].
In our study, the need for PVS or conduit in syndromic patients was comparable to earlier studies., Michielon et al. and others had described lower survival rates and lower freedom from re-intervention in syndromic patients.,, In this study, after an initial decline in EFS for syndromic patients, the survival curves crossed 22.73 years. As only 1 syndromic patient was in follow-up at that time, this result might not represent the true picture and needs to collaborate with further studies for a definitive outcome [Figure 6].
In comparing PA with classical TOF, Hickey et al. described that patients with PA have 3 times more risk for late death and only half of the patients were alive 40 years postoperatively. Other studies have shown that there is a higher risk for reoperation and PVR in PA patients.,,,, In this study, actuarial survival was not as poor as described by Hickey et al., but we did find significantly poor EFS [Figure 4]. Median EFS in patients with PA was way worse than classical TOF. As these patients are at the poorer end of the TOF spectrum to begin with and most of them require repair with homograft/conduit [Table 3], it results in high re-intervention rates.
To summarize, TOF patients have an excellent actuarial survival after complete correction but the need for repeated re-interventions is common. In all the categories except for homograft and PA, the univariate analysis showed no difference in EFS in long term. This group had significantly worse EFS and an increased need for re-interventions.
The retrospective study design and long duration of the study period are one of the major limitations of this study. Diagnostic methods, technology, indications, and timing for (re) interventions all have changed over the study period, which could have influenced our results. Retrospective nature further contributes to the difficulty in gathering detailed medical records with technical details, intra-operative information, and other confounding variables such as preoperative and postoperative outflow gradients, length of patching, and cardiopulmonary bypass timings which can influence the outcome. Further, a decision regarding the type of surgery is determined by the surgeon's preference which could have introduced potential selection bias, as children treated by a PVS procedure have friendlier RVOT anatomy, resulting in better functional outcome and prognosis. Finally, most of the patients were operated on recently and the number of patients in follow-up for more than 20 years is less which may further add to inconsistencies in analysis and difficulty in generalization of the outcome.
| Conclusions|| |
The present study adds to the knowledge that total correction of TOF can be performed with low perioperative mortality and good long-term survival, but they still have high re-intervention rates in follow-up. Our study provides important information about long-term outcomes in different surgical groups. The study is unique in the way that it showed a gradual loss of survival advantage of sparing pulmonary valve or of doing a primary complete repair. It also showed that patients with homograft or PA patients have a significantly worse outcome. Despite medical advances, TOF remains a life-long disease with long-term morbidity. It is not cured by complete repair and continuous surveillance of this cohort is important.
Financial support and sponsorship
Conflicts of interest
Abhinav Agarwal (none), Suad R Al Amer (none), Habib Al Tarif (none), Aieshah Ahmed Ismael (none) Neale Nicola Kalis (none).
| References|| |
Hoffman JI, Kaplan S. The incidence of congenital heart disease. J Am Coll Cardiol 2002;39:1890-900.
Bertranou EG, Blackstone EH, Hazelrig JB, Turner ME, Kirklin JW. Life expectancy without surgery in tetralogy of Fallot. Am J Cardiol 1978;42:458-66.
Lillehei CW, Varco RL, Cohen M, Warden HE, Gott VL, DeWall RA, et al.
The first open heart corrections of tetralogy of Fallot. A 26-31 year follow-up of 106 patients. Ann Surg 1986;204:490-502.
Murphy JG, Gersh BJ, Mair DD, Fuster V, McGoon MD, Ilstrup DM, et al
. Long-term outcome in patients undergoing surgical repair of tetralogy of Fallot. N Engl J Med 1993;329:593-9.
Nollert G, Fischlein T, Bouterwek S, Böhmer C, Klinner W, Reichart B. Long-term survival in patients with repair of tetralogy of Fallot: 36-year follow-up of 490 survivors of the first year after surgical repair. J Am Coll Cardiol 1997;30:1374-83.
Smith CA, McCracken C, Thomas AS, Spector LG, St. Louis JD, Oster ME, et al.
Long-term outcomes of tetralogy of Fallot: A study from the pediatric cardiac care consortium. JAMA Cardiol 2019;4:34-41.
Mouws EM, de Groot NM, van de Woestijne PC, de Jong PL, Helbing WA, van Beynum IM, et al.
Tetralogy of Fallot in the current era. Semin Thorac Cardiovasc Surg 2019;31:496-504.
Agarwal A, Al Amer SR, Kalis NN. Epidemiology of congenital heart disease in the Kingdom of Bahrain. Bahrain Med Bull 2020;42:192-5.
Pigula FA, Khalil PN, Mayer JE, del Nido PJ, Jonas RA. Repair of tetralogy of Fallot in neonates and young infants. Circulation 1999;100:I157-61.
Kolcz J, Pizarro C. Neonatal repair of tetralogy of Fallot results in improved pulmonary artery development without increased need for reintervention. Eur J Cardiothorac Surg 2005;28:394-9.
Al Habib HF, Jacobs JP, Mavroudis C, Tchervenkov CI, O'Brien SM, Mohammadi S, et al.
Contemporary patterns of management of tetralogy of Fallot: Data from the society of thoracic surgeons database. Ann Thorac Surg 2010;90:813-9.
Ross ET, Costello JM, Backer CL, Brown LM, Robinson JD. Right ventricular outflow tract growth in infants with palliated tetralogy of Fallot. Ann Thorac Surg 2015;99:1367-72.
Devendran V, Anjith PR, Singhi AK, Jesudian V, Sheriff EA, Sivakumar K, et al.
Tetralogy of Fallot with subarterial ventricular septal defect: Surgical outcome in the current era. Ann Pediatr Cardiol 2015;8:4-9.
Ylitalo P, Nieminen H, Pitkänen OM, Jokinen E, Sairanen H. Need of transannular patch in tetralogy of Fallot surgery carries a higher risk of reoperation but has no impact on late survival: Results of Fallot repair in Finland. Eur J Cardiothorac Surg 2015;48:91-7.
Lindberg HL, Saatvedt K, Seem E, Hoel T, Birkeland S. Single-center 50 years' experience with surgical management of tetralogy of Fallot. Eur J Cardiothorac Surg 2011;40:538-42.
Hickey EJ, Veldtman G, Bradley TJ, Gengsakul A, Manlhiot C, Williams WG, et al.
Late risk of outcomes for adults with repaired tetralogy of Fallot from an inception cohort spanning four decades. Eur J Cardiothorac Surg 2009;35:156-64.
Bové T, François K, Van De Kerckhove K, Panzer J, De Groote K, De Wolf D, et al.
Assessment of a right-ventricular infundibulum-sparing approach in transatrial-transpulmonary repair of tetralogy of Fallot. Eur J Cardiothorac Surg 2012;41:126-33.
Kim H, Sung SC, Kim SH, Chang YH, Lee HD, Park JA, et al.
Early and late outcomes of total repair of tetralogy of Fallot: Risk factors for late right ventricular dilatation. Interact Cardiovasc Thorac Surg 2013;17:956-62.
van den Bosch E, Bogers AJ, Roos-Hesselink JW, van Dijk AP, van Wijngaarden MH, Boersma E, et al
. Long-term follow-up after transatrial-transpulmonary repair of tetralogy of Fallot: Influence of timing on outcome. Eur J Cardiothorac Surg 2020;57:635-43.
Kirklin JK, Kirklin JW, Blackstone EH, Milano A, Pacifico AD. Effect of transannular patching on outcome after repair of tetralogy of Fallot. Ann Thorac Surg 1989;48:783-91.
Kim GS, Han S, Yun TJ. Pulmonary annulus preservation lowers the risk of late postoperative pulmonary valve implantation after the repair of tetralogy of Fallot. Pediatr Cardiol 2015;36:402-8.
Luijten LW, van den Bosch E, Duppen N, Tanke R, Roos-Hesselink J, Nijveld A, et al.
Long-term outcomes of transatrial-transpulmonary repair of tetralogy of Fallot. Eur J Cardiothorac Surg 2015;47:527-34.
Bacha EA, Scheule AM, Zurakowski D, Erickson LC, Hung J, Lang P, et al.
Long-term results after early primary repair of tetralogy of Fallot. J Thorac Cardiovasc Surg 2001;122:154-61.
Hickey E, Pham-Hung E, Halvorsen F, Gritti M, Duong A, Wilder T, et al.
Annulus-sparing tetralogy of Fallot repair: Low risk and benefits to right ventricular geometry. Ann Thorac Surg 2018;106:822-9.
Tamesberger MI, Lechner E, Mair R, Hofer A, Sames-Dolzer E, Tulzer G. Early primary repair of tetralogy of Fallot in neonates and infants less than four months of age. Ann Thorac Surg 2008;86:1928-35.
Sen DG, Najjar M, Yimaz B, Levasseur SM, Kalessan B, Quaegebeur JM, et al
. Aiming to preserve pulmonary valve function in tetralogy of Fallot repair: Comparing a new approach to traditional management. Pediatr Cardiol 2016;37:818-25.
Hofferberth SC, Nathan M, Marx GR, Lu M, Sleeper LA, Marshall AC, et al.
Valve-sparing repair with intraoperative balloon dilation in tetralogy of Fallot: Midterm results and therapeutic implications. J Thorac Cardiovasc Surg 2018;155:1163-73.e4.
Cuypers JA, Menting ME, Konings EE, Opić P, Utens EM, Helbing WA, et al.
Unnatural history of tetralogy of Fallot: Prospective follow-up of 40 years after surgical correction. Circulation 2014;130:1944-53.
van der Hulst AE, Hylkema MG, Vliegen HW, Delgado V, Hazekamp MG, Rijlaarsdam ME, et al.
Mild residual pulmonary stenosis in tetralogy of Fallot reduces risk of pulmonary valve replacement. Ann Thorac Surg 2012;94:2077-82.
Nørgaard MA, Lauridsen P, Helvind M, Pettersson G. Twenty-to-thirty-seven-year follow-up after repair for tetralogy of Fallot. Eur J Cardiothorac Surg 1999;16:125-30.
Kanter KR, Kogon BE, Kirshbom PM, Carlock PR. Symptomatic neonatal tetralogy of Fallot: Repair or shunt? Ann Thorac Surg 2010;89:858-63.
Seddio F, Migliazza L, Borghi A, Crupi G. Previous palliation in patients with tetralogy of Fallot does not influence the outcome of later repair. J Cardiovasc Med (Hagerstown) 2007;8:119-22.
Sousa Uva M, Lacour-Gayet F, Komiya T, Serraf A, Bruniaux J, Touchot A, et al.
Surgery for tetralogy of Fallot at less than six months of age. J Thorac Cardiovasc Surg 1994;107:1291-300.
Sousa Uva M, Chardigny C, Galetti L, Lacour Gayet F, Roussin R, Serraf A, et al.
Surgery for tetralogy of Fallot at less than six months of age. Is palliation “old-fashioned”? Eur J Cardiothorac Surg 1995;9:453-9.
Michielon G, Marino B, Formigari R, Gargiulo G, Picchio F, Digilio MC, et al.
Genetic syndromes and outcome after surgical correction of tetralogy of Fallot. Ann Thorac Surg 2006;81:968-75.
Mercer-Rosa L, Pinto N, Yang W, Tanel R, Goldmuntz E. 22q11.2 deletion syndrome is associated with perioperative outcome in tetralogy of Fallot. J Thorac Cardiovasc Surg 2013;146:868-73.
Park CS, Lee JR, Lim HG, Kim WH, Kim YJ. The long-term result of total repair for tetralogy of Fallot. Eur J Cardiothorac Surg 2010;38:311-7.
Sfyridis PG, Kirvassilis GV, Papagiannis JK, Avramidis DP, Ieromonachos CG, Zavaropoulos PN, et al.
Preservation of right ventricular structure and function following transatrial-transpulmonary repair of tetralogy of Fallot. Eur J Cardiothorac Surg 2013;43:336-42.
Balasubramanya S, Zurakowski D, Borisuk M, Kaza AK, Emani SM, Del Nido PJ, et al.
Right ventricular outflow tract reintervention after primary tetralogy of Fallot repair in neonates and young infants. J Thorac Cardiovasc Surg 2018;155:726-34.
[Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5], [Figure 6], [Figure 7]
[Table 1], [Table 2], [Table 3]