ORIGINAL ARTICLE
Year : 2015 | Volume
: 16 | Issue : 3 | Page : 85--87
Angiographic findings after supplementation with Heracleum persicum extract: Results of a randomized controlled trial
Yunes Panahi1, Bahram Pishgoo2, Amirhossein Sahebkar3
1 Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
2 Department of Cardiology, Cardiovascular Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
3 Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Metabolic Research Centre, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
Correspondence Address:
Dr. Amirhossein Sahebkar
Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, P.O. Box: 91779-48564, Iran
Background: Heracleum persicum is a common dietary spice with several traditional medicinal properties important for cardiovascular health including antioxidant, hypolipidemic, and anti-inflammatory effects. This study explored the effects of supplementation with H. persicum fruit on the angiographic findings of patients with minimal coronary artery disease (CAD).
Methods: Subjects who were diagnosed with <50% stenosis in any of their coronary arteries by angiography were selected for this trial and randomly assigned to H. persicum hydroalcoholic fruit extract (n = 15; 300 mg/day) or placebo (n = 12) for 6 months. At the end of the trial, participants underwent a second coronary angiography in order to evaluate the progression of their disease.
Results: Posttrial angiography did not reveal any improvement in the number of stenosed vessels after consumption of H. persicum extract versus placebo (P > 0.05). Similarly, there was no significant difference between the study groups in terms of disease progression and chest pain score (P > 0.05).
Conclusions: The present results do not support any clinically significant benefit of supplementation with H. persicum extract on the angiographic findings of in patients with minimal CAD.
How to cite this article:
Panahi Y, Pishgoo B, Sahebkar A. Angiographic findings after supplementation with Heracleum persicum extract: Results of a randomized controlled trial.Heart Views 2015;16:85-87
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How to cite this URL:
Panahi Y, Pishgoo B, Sahebkar A. Angiographic findings after supplementation with Heracleum persicum extract: Results of a randomized controlled trial. Heart Views [serial online] 2015 [cited 2023 Jun 2 ];16:85-87
Available from: https://www.heartviews.org/article.asp?issn=1995-705X;year=2015;volume=16;issue=3;spage=85;epage=87;aulast=Panahi;type=0 |
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